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Genome-wide investigations of the lipid accumulation product index pinpoints polygenic determinants underlying pancreatitis susceptibility.

Mammalian genome : official journal of the International Mammalian Genome Society - 15 Apr 2026

Chien Chia-Fu, Qi Zhengwei, Liu Zhengye, Du Hanze, Wan Ziqi, Chen Haotian, Bai Xiaoyin, Mi Jiarui

Abstract excerpt

The lipid accumulation product index (LAP) is a robust marker of lipid burden. However, its genetic architecture and causal relevance to pancreatitis remain poorly characterized. We performed a genome-wide association study (GWAS) of LAP in 388,213 European from UK Biobank, followed by colocalization, transcriptome-wide association studies (TWAS), LD score regression and Mendelian randomization for causal...

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PMID: 41986517
DOI: 10.1007/s00335-026-10215-6

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