Whole-Genome Analysis of HEV Under Sequential Ribavirin Pressure Reveals Early Minor Variants Predicting Resistance.

doi:10.1002/jmv.71146

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Whole-Genome Analysis of HEV Under Sequential Ribavirin Pressure Reveals Early Minor Variants Predicting Resistance.

Journal of medical virology - 1 Sept 2026

Colomer-Castell Sergi, Ibañez-Lligoña Marta, Campos Carolina, Gregori Josep, Garcia-Cehic Damir, Rando-Segura Ariadna, Ferrer Roser, Ruzo Sofía P, Cortese Maria Francesca, Tabernero David, Vico-Romero Judit, Ruiz-Cobo Juan Carlos, Buti Maria, Riveiro-Barciela Mar, Quer Josep

Abstract excerpt

Ribavirin (RBV) failures in chronic hepatitis E virus (HEV) infection may arise from genomic adaptation, yet the contribution of minor variants remains insufficiently explored. Using a shotgun metagenomics based on next-generation sequencing to obtain the full HEV genome, we analyzed longitudinal HEV populations from sequential clinical samples collected from a patient infected by Paslahepevirus balayani genotype...

Read the complete abstract on PubMed

Topics

Ribavirin
Humans
Antiviral Agents
Hepatitis E
Hepatitis E virus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Drug Resistance, Viral

Genome, Viral

Genotype

Genetic Variation

Whole Genome Sequencing

High-Throughput Nucleotide Sequencing

Amino Acid Substitution

Metagenomics

Source

Open in PubMed Open full text

Identifiers

PMID: 42725563
DOI: 10.1002/jmv.71146
PMCID: PMC13563686

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole-Genome Analysis of HEV Under Sequential Ribavirin Pressure Reveals Early Minor Variants Predicting Resistance.PMID 42725563Read ↗

Intra-host viral population dynamics during acute hepatitis E virus infection.Semantic proximity Read ↗

Sequential bottlenecks drive viral evolution in early acute hepatitis C virus infection.Semantic proximity Read ↗

Machine-learning based patient classification using Hepatitis B virus full-length genome quasispecies from Asian and European cohorts.Semantic proximity Read ↗

Genotype-specific acquisition, evolution and adaptation of characteristic mutations in hepatitis E virus.Semantic proximity Read ↗

In-Host HEV Quasispecies Evolution Shows the Limits of Mutagenic Antiviral TreatmentsSemantic proximity Read ↗

Whole genome sequencing reveals insights into hepatitis E virus genome diversity, and virus compartmentalization in chronic hepatitis E.Semantic proximity Read ↗

Emergence of resistance-associated variants during sofosbuvir treatment in chronically infected hepatitis E patients.Semantic proximity Read ↗

In-depth longitudinal study on hepatitis E virus evolution in chronic infection with ribavirin treatment failureSemantic proximity Read ↗

Immune Escape and Drug Resistance Mutations in Patients with Hepatitis B Virus Infection: Clinical and Epidemiological ImplicationsSemantic proximity Read ↗

Comparative Analysis of Within-Host Mutation Patterns and Diversity of Hepatitis C Virus Subtypes 1a, 1b, and 3a.Semantic proximity Read ↗

Single-virion Sequencing of Lamivudine Treated HBV Populations Reveal Population Evolution Dynamics and Demographic HistorySemantic proximity Read ↗

Unraveling HCV Diversity and Resistance in Viet Nam: Implications for TreatmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.