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Article

Emergence of resistance-associated variants during sofosbuvir treatment in chronically infected hepatitis E patients.

Hepatology (Baltimore, Md.) - 1 Dec 2023

Gömer André, Klöhn Mara, Jagst Michelle, Nocke Maximilian K, Pischke Sven, Horvatits Thomas, Schulze Zur Wiesch Julian, Müller Tobias, Hardtke Svenja, Cornberg Markus, Wedemeyer Heiner, Behrendt Patrick, Steinmann Eike, Todt Daniel

Abstract excerpt

BACKGROUND AND AIMS: Chronic HEV infections remain a serious problem in immunocompromised patients, as specifically approved antiviral drugs are unavailable. In 2020, a 24-week multicenter phase II pilot trial was carried out, evaluating the nucleotide analog sofosbuvir by treating nine chronically HEV-infected patients with sofosbuvir (Trial Number NCT03282474). During the study, antiviral therapy reduced virus...

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Share to Antiviral Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37334496
DOI: 10.1097/HEP.0000000000000514
PMCID: PMC10653298

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