Article
Genotype-specific acquisition, evolution and adaptation of characteristic mutations in hepatitis E virus.
Virulence - 1 Jan 2018
Ikram Aqsa, Hakim Mohamad S, Zhou Jian-Hua, Wang Wenshi, Peppelenbosch Maikel P, Pan Qiuwei
Abstract excerpt
Hepatitis E virus (HEV) infection is a major cause of acute hepatitis but also provokes chronic infection in immunocompromised patients. Although the pathogenesis and treatment outcome involve complex interplay between the virus and host, the nature of adaptive responses of HEV to the host immune system remain obscure at best. In this study, we used large-scale proteomic bioinformatics to profile characteristic...
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