Article
Whole genome sequencing reveals insights into hepatitis E virus genome diversity, and virus compartmentalization in chronic hepatitis E.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Nov 2023
Melchert Julia, Radbruch Helena, Hanitsch Leif G, Baylis Sally A, Beheim-Schwarzbach Jörn, Bleicker Tobias, Hofmann Jörg, Jones Terry C, Drosten Christian, Corman Victor M
Abstract excerpt
BACKGROUND: Hepatitis E virus (HEV) is a leading cause of acute hepatitis and can cause chronic infections in immunocompromised patients. Although HEV infections can be treated with ribavirin, antiviral efficacy is hampered by resistance mutations, normally detected by virus sequencing. OBJECTIVES: High-throughput sequencing (HTS) allows for cost-effective complete viral genome sequencing. This enables the...
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