Emergence and spread of NA-I223V and NA-S247N double-mutant A(H1N1)pdm09 influenza viruses with reduced oseltamivir susceptibility in the Netherlands and beyond, 2023 to 2026.

doi:10.2807/1560-7917.ES.2026.31.36.2600733

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Article

Emergence and spread of NA-I223V and NA-S247N double-mutant A(H1N1)pdm09 influenza viruses with reduced oseltamivir susceptibility in the Netherlands and beyond, 2023 to 2026.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin - 1 Sept 2026

Felix Garza Zandra, Eggink Dirk, Bagheri Mariam, van den Brink Sharon, Goderski Gabriel, Pronk Mark, Lexmond Pascal, Hooiveld Mariëtte, van Gageldonk-Lafeber Rianne, Koel Björn, Fouchier Ron, Meijer Adam

Abstract excerpt

In 2023/24, A(H1N1)pdm09 influenza viruses with neuraminidase (NA)-S247N emerged in NA-clade C.5.3.3 carrying NA-I223V, spread internationally, then faded. Such double mutants reappeared sporadically in 2024/25. They expanded again in 2025/26 in NA-clade D.3 viruses carrying NA-S247N after acquiring NA-I223V in Europe - notably Spain, the Netherlands, Finland and France, and beyond. Dutch double mutants from both...

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Topics

Oseltamivir
Antiviral Agents
Neuraminidase
Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Influenza A Virus, H1N1 Subtype

Influenza, Human

Netherlands

Drug Resistance, Viral

Mutation

Microbial Sensitivity Tests

Viral Proteins

Source

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Identifiers

PMID: 42725368
DOI: 10.2807/1560-7917.ES.2026.31.36.2600733
PMCID: PMC13570233

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