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Antiviral Susceptibility of Highly Pathogenic Avian Influenza A(H5N1) Viruses Circulating Globally in 2022-2023.

The Journal of infectious diseases - 14 Jun 2024

Andreev Konstantin, Jones Jeremy C, Seiler Patrick, Kandeil Ahmed, Turner Jasmine C M, Barman Subrata, Rubrum Adam M, Webby Richard J, Govorkova Elena A

Abstract excerpt

The antiviral susceptibility of currently circulating (2022-2023) highly pathogenic avian influenza (HPAI) A(H5N1) viruses was assessed by genotypic and phenotypic approaches. The frequency was low for neuraminidase (NA) and polymerase acidic (PA) substitutions associated with reduced inhibition by NA inhibitors (21/2698, 0.78%) or the PA inhibitor baloxavir (14/2600, 0.54%). Phenotypic testing of 22 clade...

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PMID: 37770028
DOI: 10.1093/infdis/jiad418
PMCID: PMC11175693

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