Susceptibility of Brazilian influenza A(H1N1)pdm09 viruses to neuraminidase inhibitors in the 2014-2016 seasons: Identification of strains bearing mutations associated with reduced inhibition profile.

doi:10.1016/j.antiviral.2018.03.010

Article

Susceptibility of Brazilian influenza A(H1N1)pdm09 viruses to neuraminidase inhibitors in the 2014-2016 seasons: Identification of strains bearing mutations associated with reduced inhibition profile.

Antiviral research - 1 Jun 2018

Matos Aline R, Resende Paola C, Miranda Milene D, Garcia Cristiana C, Caetano Braulia C, Lopes Jonathan C O, Debur Maria C, Cury Ana L F, Vianna Lucas A, Lima Magliones C, Schirmer Marcelo, Gubareva Larissa, Hurt Aeron C, Brown David W, Siqueira Marilda M

Abstract excerpt

Neuraminidase inhibitors (NAIs) are the main class of antivirals currently used for the treatment of influenza infections. As influenza viruses are constantly evolving, drug-resistance can emerge resulting in reduced effectiveness of treatment. This study evaluated the presence of molecular markers associated with NAI susceptibility in 724 influenza A(H1N1)pdm09 positive samples from Brazilian surveillance system...

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Susceptibility of Brazilian influenza A(H1N1)pdm09 viruses to neuraminidase inhibitors in the 2014-2016 seasons: Identification of strains bearing mutations associated with reduced inhibition profile.

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