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Article

Detection and characterization of antiviral-resistant viruses during the influenza season of 2024-25.

Microbiology spectrum - 1 Sept 2026

Patel Mira C, Nguyen Ha T, Pascua Philippe Noriel Q, Lopez-Esteva Mercedes, Champion Chloe, Mishin Vasiliy P, Di Han, Lacek Kristine, Kirby Marie K, Bateman Allen, Sullivan Maureen, Trow Susan, Laplante Jennifer, St George Kirsten, Rambo-Martin Benjamin, Merced-Morales Angiezel, Budd Alicia, Kondor Rebecca J, Davis Charles T, Gubareva Larisa V

Abstract excerpt

During the high severity season of 2024-25, CDC with public health partners sequenced and analyzed genomes of >10,000 influenza viruses for antiviral resistance markers. Available sequence-flagged and representative viruses were tested with antivirals using in vitro assays. In the US, three oseltamivir-resistant A(H3N2) viruses had treatment-emergent neuraminidase (NA) mutations, either E119V or R292K....

Read the complete abstract on PubMed

Topics

Antiviral Agents
Humans
Drug Resistance, Viral
Influenza, Human

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Neuraminidase

Influenza A Virus, H1N1 Subtype

Influenza A Virus, H3N2 Subtype

Oseltamivir

Animals

Phylogeny

Dibenzothiepins

Viral Proteins

Morpholines

Dogs

Mutation

Pyridones

Triazines

Seasons

Source

Open in PubMed Open full text

Identifiers

PMID: 42560041
DOI: 10.1128/spectrum.01514-26
PMCID: PMC13532263

Provenance

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