Article
Multicountry Spread of Influenza A(H1N1)pdm09 Viruses with Reduced Oseltamivir Inhibition, May 2023-February 2024.
Emerging infectious diseases - 1 Jul 2024
Patel Mira C, Nguyen Ha T, Pascua Philippe Noriel Q, Gao Rongyuan, Steel John, Kondor Rebecca J, Gubareva Larisa V
Abstract excerpt
Since May 2023, a novel combination of neuraminidase mutations, I223V + S247N, has been detected in influenza A(H1N1)pdm09 viruses collected in countries spanning 5 continents, mostly in Europe (67/101). The viruses belong to 2 phylogenetically distinct groups and display ≈13-fold reduced inhibition by oseltamivir while retaining normal susceptibility to other antiviral drugs.
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