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Article

Influenza neuraminidase mutations and resistance to neuraminidase inhibitors.

Emerging microbes & infections - 1 Dec 2024

Xu Jiapeng, Luo Qiting, Huang Yuanyuan, Li Jieyu, Ye Wei, Yan Ran, Zhou Xinrui, He Zhendan, Liu Ge, Zhu Qinchang

Abstract excerpt

Mutations in influenza virus neuraminidase (NA) can lead to viral resistance to NA inhibitors (NAIs). To update global influenza NA mutations and resistance to NAIs, we investigated epidemic information from global regions for NAIs-resistant influenza strains and analyzed their NA mutations. Drug-resistant mutations in NA, especially new mutations occurred in 2016-2024, were updated. The H274Y mutation in N1, a...

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Identifiers

PMID: 39530458
DOI: 10.1080/22221751.2024.2429627
PMCID: PMC11600549

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