Article
Evaluation of HA-D222G/N polymorphism using targeted NGS analysis in A(H1N1)pdm09 influenza virus in Russia in 2018-2019.
PloS one - 1 Jan 2021
Danilenko Alexey V, Kolosova Natalia P, Shvalov Alexander N, Ilyicheva Tatyana N, Svyatchenko Svetlana V, Durymanov Alexander G, Bulanovich Julia A, Goncharova Natalia I, Susloparov Ivan M, Marchenko Vasiliy Y, Tregubchak Tatyana V, Gavrilova Elena V, Maksyutov Rinat A, Ryzhikov Alexander B
Abstract excerpt
Outbreaks of influenza, which is a contagious respiratory disease, occur throughout the world annually, affecting millions of people with many fatal cases. The D222G/N mutations in the hemagglutinin (HA) gene of A(H1N1)pdm09 are associated with severe and fatal human influenza cases. These mutations lead to increased virus replication in the lower respiratory tract (LRT) and may result in life-threatening...
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