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Article

Prognostic Significance of Secondary-Type Mutations in NPM1-Mutated Acute Myeloid Leukemia.

Cancer medicine - 1 Sept 2026

Yang Kun, Luo Hongmei, Xiang Bing, Dai Yang, Gong Yuping, Huang Jie, Li Jianjun, Jia Yongqian, Guo Yong, Zheng Yuhuan, Ma Hongbing

Abstract excerpt

NPM1 is among the most frequently mutated genes in acute myeloid leukemia (AML), and NPM1-mutated AML is generally associated with a favorable prognosis. However, substantial prognostic heterogeneity exists within this population. The prognostic significance of secondary-type mutations (STMs) in NPM1-mutated AML remains controversial. In this retrospective study of 179 patients with NPM1-mutated AML, the...

Read the complete abstract on PubMed

Topics

Humans
Nucleophosmin
Leukemia, Myeloid, Acute
Mutation
Prognosis
Female
Nuclear Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

fms-Like Tyrosine Kinase 3

Aged

Male

Adult

Retrospective Studies

Aged, 80 and over

Young Adult

DNA Methyltransferase 3A

DNA (Cytosine-5-)-Methyltransferases

Source

Open in PubMed Open full text

Identifiers

PMID: 42723171
DOI: 10.1002/cam4.72278
PMCID: PMC13562606

Genes

NPM1
FLT3
DNMT3A
ELN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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Prognostic Significance of Secondary-Type Mutations in NPM1-Mutated Acute Myeloid Leukemia.PMID 42723171Read ↗

Secondary-type mutations do not impact outcome in NPM1-mutated acute myeloid leukemia - implications for the European LeukemiaNet risk classification.Semantic proximity Read ↗

Secondary‐type mutations do not impact prognosis in acute myelogenous leukemia AML with mutated NPM1Semantic proximity Read ↗

Mutations highly specific for secondary AML are associated with poor outcomes in ELN favorable risk NPM1-mutated AML.Semantic proximity Read ↗

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The correlation of next-generation sequencing-based genotypic profiles with clinicopathologic characteristics in NPM1-mutated acute myeloid leukemia.Semantic proximity Read ↗

Favorable prognostic impact of NPM1 mutations in older patients with cytogenetically normal de novo acute myeloid leukemia and associated gene- and microRNA-expression signatures: a Cancer and Leukemia Group B study.Semantic proximity Read ↗

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Unravelling co-mutational patterns with prognostic implications in NPM1 mutated adult acute myeloid leukemia - a HARMONY study.Semantic proximity Read ↗

The combination of NPM1, DNMT3A, and IDH1/2 mutations leads to inferior overall survival in AMLSemantic proximity Read ↗

High NPM1-mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML.Semantic proximity Read ↗

Genetic biomarkers identify a subgroup of high-risk patients within low-risk NPM1-mutated acute myeloid leukemia.Semantic proximity Read ↗

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