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Article

Prognostic implications of myelodysplasia-related gene mutations in NPM1-mutated acute myeloid leukemia: a systematic review and meta-analysis.

Haematologica - 1 Sept 2026

Chang Yu-Sung, Lee Yi-Wei, Liu Chieh-Yu, Othman Jad, Eckardt Jan-Niklas, Zhou Qianghua, Tien Feng-Ming, Lyu Ting-Wei, Tsai Xavier Cheng-Hong, Lin Chien-Chin, Chang Hong, Ko Bor-Sheng, Chou Wen-Chien, Röllig Christoph, Russell Nigel, Dillon Richard, Hou Hsin-An

Abstract excerpt

NPM1-mutated (NPM1mut) acute myeloid leukemia (AML) is generally classified as favorable-risk under the 2022 European LeukemiaNet (ELN-2022) guidelines, except in the presence of FLT3-internal tandem duplication or adverse-risk cytogenetics. However, the prognostic significance of co-occurring myelodysplasia-related gene (MRG) mutations remains unclear, with prior studies yielding inconsistent results. To clarify...

Read the complete abstract on PubMed

Topics

Humans
Nucleophosmin
Mutation
Leukemia, Myeloid, Acute
Prognosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Myelodysplastic Syndromes

Nuclear Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 41742883
DOI: 10.3324/haematol.2025.288081
PMCID: PMC13530955

Genes

ELN
NPM1
RUNX1
ASXL1
BCOR
FLT3
SF3B1
SRSF2
STAG2
U2AF1
ZRSR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

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