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Article

Mutations highly specific for secondary AML are associated with poor outcomes in ELN favorable risk NPM1-mutated AML.

Blood advances - 12 Mar 2024

Chan Onyee, Al Ali Najla, Tashkandi Hammad, Ellis Austin, Ball Somedeb, Grenet Justin, Hana Caroline, Deutsch Yehuda, Zhang Ling, Hussaini Mohammad, Song Jinming, Yun Seongseok, Talati Chetasi, Kuykendall Andrew, Padron Eric, Walker Alison, Roboz Gail, Desai Pinkal, Sallman David, Sweet Kendra, Komrokji Rami, Lancet Jeffrey

Abstract excerpt

ABSTRACT: Acute myeloid leukemia (AML) is a heterogeneous malignancy with outcomes largely predicted by genetic abnormalities. Mutations of NPM1 are common in AML, occurring in ∼30% of cases, and generally considered a favorable risk factor. Mutations highly specific for secondary AML (sMut) have been shown to confer poor prognosis, but the overall impact of these mutations in the setting of favorable-risk AML...

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Identifiers

PMID: 38170740
DOI: 10.1182/bloodadvances.2023011173
PMCID: PMC10907389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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