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Article

Hypothesis-based investigation of known AD risk variants reveals the genetic underpinnings of neuropathological lesions observed in Alzheimer's-type dementia.

Acta neuropathologica - 18 Oct 2024

Laureyssen Celeste, Küçükali Fahri, Van Dongen Jasper, Gawor Klara, Tomé Sandra O, Ronisz Alicja, Otto Markus, von Arnim Christine A F, Van Damme Philip, Vandenberghe Rik, Thal Dietmar Rudolf, Sleegers Kristel

Abstract excerpt

Alzheimer's disease (AD) is the leading cause of dementia worldwide. Besides neurofibrillary tangles and amyloid beta (Aβ) plaques, a wide range of co-morbid neuropathological features can be observed in AD brains. Since AD has a very strong genetic background and displays a wide phenotypic heterogeneity, this study aims at investigating the genetic underpinnings of co-morbid and hallmark neuropathological...

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Identifiers

PMID: 39424714
DOI: 10.1007/s00401-024-02815-w
PMCID: PMC11489263

Genes

APOE
ANK3
APH1B
BIN1
TPCN1
UMAD1
USP6NL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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