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Thyroid carcinoma‐featured telomerase activation and telomere maintenance: Biology and translational/clinical significance

1 Nov 2022

Abstract excerpt

BACKGROUND: Telomerase is a ribonucleoprotein complex consisting of a catalytic component telomerase reverse transcriptase (TERT), internal RNA template and other co-factors, and its essential function is to synthesize telomeric DNA, repetitive TTAGGG sequences at the termini of linear chromosomes. Telomerase is silent in normal human follicular thyroid cells, primarily due to the TERT gene being tightly...

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PMID: 36394204
DOI: 10.1002/ctm2.1111

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