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Article

Spectrum of TERT promoter mutations and mechanisms of activation in thyroid cancer

13 Aug 2019

Abstract excerpt

BACKGROUND: Reactivation of telomerase reverse transcriptase (TERT) is an important event in cancer. Two hotspot mutations in the TERT promoter region, c.-124C > T (C228T) and c.-146C > T (C250T), occur in various cancer types including thyroid cancer. They generate de novo binding sites for E-twenty-six (ETS) transcription factors causing increased TERT transcription. The aim of this study was to search for...

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PMID: 31408918
DOI: 10.1002/cam4.2467

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