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Article

An architectural role of specific RNA-RNA interactions in oskar granules.

Nature cell biology - 1 Nov 2024

Bose Mainak, Rankovic Branislava, Mahamid Julia, Ephrussi Anne

Abstract excerpt

Ribonucleoprotein (RNP) granules are membraneless condensates that organize the intracellular space by compartmentalization of specific RNAs and proteins. Studies have shown that RNA tunes the phase behaviour of RNA-binding proteins, but the role of intermolecular RNA-RNA interactions in RNP granules in vivo remains less explored. Here we determine the role of a sequence-specific RNA-RNA kissing-loop interaction...

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Identifiers

PMID: 39354131
DOI: 10.1038/s41556-024-01519-3
PMCID: PMC11567897

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