Article
Self-interaction of NPM1 modulates multiple mechanisms of liquid-liquid phase separation.
Nature communications - 26 Feb 2018
Mitrea Diana M, Cika Jaclyn A, Stanley Christopher B, Nourse Amanda, Onuchic Paulo L, Banerjee Priya R, Phillips Aaron H, Park Cheon-Gil, Deniz Ashok A, Kriwacki Richard W
Abstract excerpt
Nucleophosmin (NPM1) is an abundant, oligomeric protein in the granular component of the nucleolus with roles in ribosome biogenesis. Pentameric NPM1 undergoes liquid-liquid phase separation (LLPS) via heterotypic interactions with nucleolar components, including ribosomal RNA (rRNA) and proteins which display multivalent arginine-rich linear motifs (R-motifs), and is integral to the liquid-like nucleolar matrix....
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