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Article

Impact of IL-21 on CAR T-cell manufacturing: phenotypic, metabolic, and functional outcomes.

Frontiers in immunology - 1 Jan 2026

Val-Casals Maria, Altuna Ane, Pérez-Amill Lorena, Armand-Ugón Mercedes, Peña Sergio, López-Pecino Ana, Colomer Dolors, Esteve Jordi, Juan Manel, Klein-González Nela

Abstract excerpt

Introduction: Cytokines used during chimeric antigen receptor (CAR) T-cell manufacturing can influence product differentiation and functional fitness. Methods: We investigated whether adding IL-21 to an IL-7 + IL-15 expansion regimen modulates CD84-directed CAR T cells (CART84) targeting CD84+ acute myeloid leukemia (AML), using IL-7 + IL-15 alone as the primary comparator and IL-2 as a preclinical benchmark....

Read the complete abstract on PubMed

Topics

Interleukins
Humans
Interleukin-21
Animals
Immunotherapy, Adoptive
Receptors, Chimeric Antigen

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Leukemia, Myeloid, Acute

Interleukin-7

Interleukin-15

Mice

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 42712421
DOI: 10.3389/fimmu.2026.1819376
PMCID: PMC13549998

Genes

CD84

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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