Article

Generation and proof-of-concept for allogeneic CD123 CAR-Delta One T (DOT) cells in Acute Myeloid Leukemia

2022-03-17

Abstract excerpt

<h4>ABSTRACT</h4> Chimeric Antigen Receptor (CAR)-T cells have emerged as a breakthrough treatment for relapse/refractory (r/r) hematological tumors, showing impressive complete remission rates in B-cell malignancies. However, around 50% of the patients relapse before 1-year post-treatment. T-cell “fitness” is critical to prolong the persistence and activity of the adoptively transferred product. Allogeneic T cel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3d72ec02-af87-519b-aeaa-481df6f3e3de
DOI: 10.1101/2022.03.15.484289

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Generation and proof-of-concept for allogeneic CD123 CAR-Delta One T (DOT) cells in Acute Myeloid LeukemiaDOI 10.1101/2022.03.15.484289Read

Transgenic Expression of IL15 Retains CD123-Redirected T Cells in a Less Differentiated State Resulting in Improved Anti-AML Activity in Autologous AML PDX ModelsSemantic proximity Read

Epitope Engineered Human Haematopoietic Stem Cells are Shielded from CD123-targeted ImmunotherapySemantic proximity Read

Chimeric Antigen Receptor T-Cell Therapy: What We Expect SoonSemantic proximity Read

In-depth comparative characterization identifies scalable CD123-CAR-NK cells as promising strategy to combat AMLSemantic proximity Read

Optimization of universal allogeneic CAR-T cells combining CRISPR and transposon-based technologies for treatment of acute myeloid leukemiaSemantic proximity Read

Engineering CAR-NK cells to secrete IL15 sustains their anti-AML functionality, but is associated with systemic toxicitiesSemantic proximity Read

Current status and perspective of CAR-T and CAR-NK cell therapy trials in GermanySemantic proximity Read

CAR-T cells with the CD38-CD73-Tim-3-HLA-DR+ phenotype predict the efficacy of tisagenlecleucel as a treatment for B cell precursor ALL.Semantic proximity Read

WITHDRAWN: High-throughput preclinical screening of CD123 scFv to design 3rd generation of CAR T-cell in the treatment of BPDCN patientSemantic proximity Read

Clonal Expansion of Bone Marrow CD8+ T Cells in Acute Myeloid Leukemia Patients at New Diagnosis and Post ChemotherapySemantic proximity Read

TriLeukeVax: A CD80/IL-15/IL-15Rα Expressing Autologous AML Cell Vaccine Elicits Robust Anti-Leukemic Cytolytic ActivitySemantic proximity Read

The tandem CD33-CLL1 CAR-T as an approach to treat acute myeloid leukemia.Semantic proximity Read