Article

A mechanistically novel peptide agonist of the IL-7 receptor that addresses limitations of IL-7 cytokine therapy

2023-05-24

Abstract excerpt

Interleukin (IL)-7 is broadly active on T-cell populations, and modified versions have been clinically evaluated for a variety of therapeutic applications, including cancer, lymphopenia and infectious diseases; and found to be relatively well-tolerated and biologically active. Here we describe novel IL-7R agonists that are unrelated in structure to IL-7, bind to the receptor subunits differently from IL-7, but clo...

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Literature Corpus work: 00688f7b-4461-538f-af2b-634cc38e836f
DOI: 10.1101/2023.05.24.542196

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A mechanistically novel peptide agonist of the IL-7 receptor that addresses limitations of IL-7 cytokine therapyDOI 10.1101/2023.05.24.542196Read

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