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Applying an evolutionary mismatch framework to understand disease susceptibility

11 Sept 2023

Abstract excerpt

Noncommunicable diseases (NCDs) are on the rise worldwide. Obesity, cardiovascular disease, and type 2 diabetes are among a long list of "lifestyle" diseases that were rare throughout human history but are now common. The evolutionary mismatch hypothesis posits that humans evolved in environments that radically differ from those we currently experience; consequently, traits that were once advantageous may now be...

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PMID: 37695771
DOI: 10.1371/journal.pbio.3002311

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