Article
Inferring Genome-Wide Correlations of Mutation Fitness Effects between Populations.
Molecular biology and evolution - 27 Sept 2021
Huang Xin, Fortier Alyssa Lyn, Coffman Alec J, Struck Travis J, Irby Megan N, James Jennifer E, León-Burguete José E, Ragsdale Aaron P, Gutenkunst Ryan N
Abstract excerpt
The effect of a mutation on fitness may differ between populations depending on environmental and genetic context, but little is known about the factors that underlie such differences. To quantify genome-wide correlations in mutation fitness effects, we developed a novel concept called a joint distribution of fitness effects (DFE) between populations. We then proposed a new statistic w to measure the DFE...
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