Article
An Acidic Tubulointerstitial Microenvironment Delays Cell-Cycle Progression in Proximal Tubule Cells and Fibroblasts and Synergizes With Lactate to Drive Phenotypic Alterations.
Acta physiologica (Oxford, England) - 1 Oct 2026
Schulz Marie-Christin, Dubourg Virginie, Schaude Lea, Schröder Natalie, Janßen Eva, Görlich Isabelle, Ruhs Stefanie, Kopf Michael, Gekle Michael
Abstract excerpt
BACKGROUND: Chronic kidney disease (CKD) is characterized by progressive tubulointerstitial inflammation and fibrosis, particularly affecting the proximal tubule. Both proximal tubular epithelial cells and interstitial fibroblasts contribute to CKD progression through cell-cycle arrest and phenotypic transitions. The aim of the present study was to address whether lactic acidosis contributes to these processes....
Read the complete abstract on PubMedTopics
- Humans
- Kidney Tubules, Proximal
- Fibroblasts
- Cell Cycle
- Lactic Acid