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Article

Multi-omics Mendelian Randomization Prioritizes Neutrophil Extracellular Trap-related Genes Associated with Atrial Fibrillation Risk.

Endocrine, metabolic & immune disorders drug targets - 1 Jan 2026

Zhou Ruya, Zhang Pengzhao, Zhu Feiyu, Lian Tingting, Wu Xianjun

Abstract excerpt

INTRODUCTION: Neutrophil extracellular traps (NETs) participate in thrombosis, inflammation, and cardiovascular remodeling, yet whether NET-related genes (NRGs) are associated with atrial fibrillation (AF) risk across multiple molecular layers remains unclear. This study used a multiomics Mendelian randomization framework to prioritize NRGs supported by methylation, expression, and protein quantitative trait loci...

Read the complete abstract on PubMed

Topics

Humans
Mendelian Randomization Analysis
Atrial Fibrillation
Quantitative Trait Loci
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Extracellular Traps

Genome-Wide Association Study

Multiomics

DNA Methylation

Risk Factors

Source

Identifiers

PMID: 42693724
DOI: 10.2174/0118715303483446260804045231

Genes

C3
MAPK3
STAT3
CTSC
LPAR3
THBD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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