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Mendelian randomization reveals interactions of the blood proteome and immunome in mitral valve prolapse

6 Jun 2024

Abstract excerpt

BACKGROUND: Mitral valve prolapse (MVP) is a common heart disorder characterized by an excessive production of proteoglycans and extracellular matrix in mitral valve leaflets. Large-scale genome-wide association study (GWAS) underlined that MVP is heritable. The molecular underpinnings of the disease remain largely unknown. METHODS: We interrogated cross-modality data totaling more than 500,000 subjects including...

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PMID: 38844506
DOI: 10.1038/s43856-024-00530-x

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