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Article

Epigenetic Mechanisms Linking Chronic Obstructive Pulmonary Disease and Atrial Fibrillation: A Multi-Omics Mendelian Randomization Study.

International journal of chronic obstructive pulmonary disease - 1 Jan 2026

Zhang MiaoAn, Li TianFeng, Tan LingLin, Yu Jinhua, Yao Qiying, Chen Liang

Abstract excerpt

Background and Objective: Chronic obstructive pulmonary disease (COPD) and atrial fibrillation (AF) frequently co-occur, yet the underlying molecular mechanisms remain unclear. We assessed whether genetic liability to COPD increases AF risk and mapped epigenetic mediators using multi-omics data. Methods: We integrated genome-wide association data for COPD and AF with epigenome-wide DNA methylation profiles and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41859015
DOI: 10.2147/COPD.S563463
PMCID: PMC12997855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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