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Article

GWAS of Tau-Neurodegeneration Mismatch Identifies New Risk Loci for Susceptibility to Tau.

CNS neuroscience & therapeutics - 1 Sept 2026

Nabizadeh Fardin, Mohamadi Hanieh

Abstract excerpt

BACKGROUND: In Alzheimer's disease (AD), neurodegeneration is primarily attributed to the accumulation of tau neurofibrillary tangles. However, the distribution patterns of both tau pathology and neurodegeneration vary across different brain regions and among individuals. Moreover, multiple factors may influence the relationship between tau burden and neurodegenerative processes. Identifying the genetic...

Read the complete abstract on PubMed

Topics

Humans
Genome-Wide Association Study
tau Proteins
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Alzheimer Disease

Male

Aged

Aged, 80 and over

Genetic Loci

Magnetic Resonance Imaging

Positron-Emission Tomography

Source

Open in PubMed Open full text

Identifiers

PMID: 42678350
DOI: 10.1002/cns.71125
PMCID: PMC13532572

Genes

AKAP9
MAF
STXBP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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