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Article

Investigating the causal role of smoking in gout: A triangulation approach combining NHANES data, genetic correlation, and Mendelian randomization.

Medicine - 28 Aug 2026

Wei Qiaofeng, Li Lanlan, Lv Fang, Du Qing, Zhang Hongju

Abstract excerpt

The relationship between smoking and the development of gout is not well understood. To address this, we adopted a triangulation framework that integrates observational analysis, genetic correlation estimation, and two-sample Mendelian randomization (MR) to examine whether smoking confers a causal risk for gout. We first performed a cross-sectional analysis using information for 13,626 participants from the...

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Topics

Humans
Gout
Mendelian Randomization Analysis
Nutrition Surveys
Smoking
Cross-Sectional Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genome-Wide Association Study

Female

Male

Middle Aged

Risk Factors

Adult

Linkage Disequilibrium

Genetic Predisposition to Disease

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 42675747
DOI: 10.1097/MD.0000000000050449
PMCID: PMC13529097

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