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Article

Using multiple Mendelian randomization approaches and genetic correlations to understand obesity, urate, and gout.

Scientific reports - 7 Sept 2021

Adams Charleen D, Boutwell Brian B

Abstract excerpt

Observational studies suggest relationships between obesity, urate, and gout but are possibly confounded. We assessed whether genetically determined obesity, higher urate (and related traits), and gout were causal using multiple Mendelian randomization (MR) approaches and linkage disequilibrium score regression for genetic correlations (rg). For data, we used genome-wide association study summary statistics...

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Identifiers

PMID: 34493793
DOI: 10.1038/s41598-021-97410-4
PMCID: PMC8423843

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