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[Causal relationship between genetically determined childhood obesity and serum uric acid levels and gout in adults: a two-sample Mendelian randomization study].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] - 6 Feb 2026

Li M L, Wang Z X, Deng M Q, Ma Y H, Li Y, Xu L N

Abstract excerpt

Obesity is a significant risk factor for developing hyperuricemia and gout. This study aims to exploring the causal relationship between childhood obesity and serum uric acid (SUA) levels and gout in adults in a Mendelian randomization (MR) framework. The Genome-wide association study (GWAS) data for childhood obesity were obtained from the Early Growth Genetics Consortium, published in 2012, involving 13 848...

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PMID: 41606978
DOI: 10.3760/cma.j.cn112150-20250307-00179

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