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Article

MMP-2 rs243865 Polymorphism as a Risk Modifier of Hepatocellular Carcinoma in Taiwanese Males, Smokers and Alcohol Consumers.

Anticancer research - 1 Sept 2026

Yueh Te-Cheng, Wu Ming-Hsien, Yang Mei-Due, Lu Meng-Chun, Shao Yen-Chen, Ke Tao-Wei, Wang Zhi-Hong, Chen Chi-An, Tsai Chia-Wen, Bau DA-Tian, Chang Wen-Shin

Abstract excerpt

BACKGROUND/AIM: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. Matrix metalloproteinase-2 (MMP-2) plays an important role in extracellular matrix remodeling and HCC progression. This study investigated the associations of two functional MMP-2 promoter polymorphisms, rs243865 and rs2285053, with HCC susceptibility in a Taiwanese population and explored their...

Read the complete abstract on PubMed

Topics

Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Matrix Metalloproteinase 2

Carcinoma, Hepatocellular

Liver Neoplasms

Alcohol Drinking

Genetic Predisposition to Disease

Middle Aged

Case-Control Studies

Polymorphism, Single Nucleotide

Smoking

Taiwan

Risk Factors

Genotype

Female

Aged

Promoter Regions, Genetic

Gene-Environment Interaction

Source

Identifiers

PMID: 42674711
DOI: 10.21873/anticanres.18339

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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