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Insights From Matrix Metalloproteinase-2 Genotypes to Decipher the Genetic Architecture of Bladder Cancer Risk.

Anticancer research - 1 Apr 2026

Liao Cheng-Hsi, Chang Wen-Shin, Chang Shu-Yu, Wang Yun-Chi, Chen Jaw-Chyun, Shih Hou-Yu, Chang Chao-Hsiang, Chen Wen-Chi, Bau DA-Tian, Tsai Chia-Wen

Abstract excerpt

BACKGROUND/AIM: Bladder cancer (BLCA) is a prevalent malignancy globally, particularly in Taiwan, where its incidence continues to rise. While environmental exposures such as smoking play critical roles in BLCA etiology, genetic predispositions also contribute significantly. Matrix metalloproteinase-2 (MMP-2), a key enzyme involved in extracellular matrix remodeling, has been implicated in BLCA progression. This...

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PMID: 41895741
DOI: 10.21873/anticanres.18079

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