Phenotypic plasticity and competition shape therapy sequencing in HER2+/HER2- breast cancer: A mathematical framework.

Abstract excerpt

Tumour heterogeneity and phenotypic plasticity are major drivers of treatment failure in cancer, enabling rapid adaptation under therapeutic pressure. In HER2-positive (HER2+) breast cancer, tumours often contain both HER2+ and HER2-negative (HER2-) cells whose interactions complicate schedule design. We develop a compact ordinary differential equation framework for intratumoral HER2+/- dynamics that integrates...

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• Breast Neoplasms
• Erb-b2 Receptor Tyrosine Kinases
• Models, Biological
• Paclitaxel
• Phenotype