Article
Mutation of putative phosphorylation sites in the free fatty acid receptor 1: Effects on signaling, receptor phosphorylation, and internalization.
Molecular and cellular endocrinology - 5 Apr 2022
Guzmán-Silva Alejandro, Martínez-Morales Juan Carlos, Medina Luz Del Carmen, Romero-Ávila M Teresa, Villegas-Comonfort Sócrates, Solís Karina Helivier, García-Sáinz J Adolfo
Abstract excerpt
Free fatty acid receptor 1 phosphorylation sites were studied using mutants, including a) a mutant with T215V in the third intracellular loop (3IL), b) another with changes in the carboxyl terminus (C-term): T287V, T293V, S298A, and c) a mutant with all of these changes (3IL/C-term). Agonist-induced increases in intracellular calcium were similar between cells expressing wild-type or mutant receptors. In...
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