Article
Lumen charge governs gated ion transport in β-barrel nanopores.
Nature nanotechnology - 1 Jan 2026
Mayer Simon Finn, Mitsioni Marianna Fanouria, Robin Paul, van den Heuvel Lukas, Ronceray Nathan, Marcaida Maria Jose, Abriata Luciano A, Krapp Lucien F, Anton Jana S, Soussou Sarah, Jeanneret-Grosjean Justin, Fulciniti Alessandro, Möller Alexia, Vacle Sarah, Feletti Lely, Brinkerhoff Henry, Laszlo Andrew H, Gundlach Jens H, Emmerich Theo, Dal Peraro Matteo, Radenovic Aleksandra
Abstract excerpt
β-Barrel nanopores are involved in crucial biological processes, from ATP export in mitochondria to bacterial resistance, and represent a promising platform for emerging sequencing technologies. However, in contrast to ion channels, the understanding of the fundamental principles governing ion transport through these nanopores remains largely unexplored. Here we integrate experimental, numerical and theoretical...
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