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Article

Exendin-4 promotes the vascular smooth muscle cell re-differentiation through AMPK/SIRT1/FOXO3a signaling pathways.

Atherosclerosis - 1 Sept 2018

Liu Zihan, Zhang Mengqian, Zhou Tengfei, Shen Qiang, Qin Xiaomei

Abstract excerpt

BACKGROUND AND AIMS: The phenotype switching of vascular smooth muscle cells (VSMCs) plays a key role during development and progression of vascular remodeling diseases. Recent studies show that GLP-1 can inhibit intima thickening to delay the progression of atherosclerotic plaques. The purpose of this study was to investigate the role of Exendin-4, a GLP-1 receptor agonist, in VSMCs phenotype switching and the...

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AMP-Activated Protein Kinases
Calponins
Carotid Artery Injuries
Cell Plasticity
Cell Shape

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Forkhead Box Protein O3

Myocytes, Smooth Muscle

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Identifiers

PMID: 30036742
DOI: 10.1016/j.atherosclerosis.2018.07.016

Genes

SIRT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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