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SIRT3 (Sirtuin-3) Prevents Ang II (Angiotensin II)-Induced Macrophage Metabolic Switch Improving Perivascular Adipose Tissue Function.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2021

Wei (魏彤) Tong, Gao (高晶) Jing, Huang (黄程淋) Chenglin, Song (宋蓓) Bei, Sun (孙孟炜) Mengwei, Shen (沈伟利) Weili

Abstract excerpt

OBJECTIVE: Infiltrated macrophages actively promote perivascular adipose tissue remodeling and represent a dominant population in the perivascular adipose tissue microenvironment of hypertensive mice. However, the role of macrophages in initiating metabolic inflammation remains uncertain. SIRT3 (sirtuin-3), a NAD-dependent deacetylase, is sensitive to metabolic status and mediates adaptation responses. In this...

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Adipose Tissue, Brown
Angiotensin II
Cell Plasticity
Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pyruvate Dehydrogenase (Lipoamide)

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PMID: 33327751
DOI: 10.1161/ATVBAHA.120.315337

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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