Article
Mutual regulation between β-TRCP mediated REST protein degradation and Kv1.3 expression controls vascular smooth muscle cell phenotype switch.
Atherosclerosis - 1 Nov 2020
Ye Meng, Guo Xiangjiang, Wang Han, Wang Yuli, Qian Xin, Deng Haoyu, Wang Weilun, Yang Shuofei, Ni Qihong, Chen Jiaquan, Lv Lei, Zhao Yiping, Xue Guanhua, Li Yinan, Zhang Lan
Abstract excerpt
BACKGROUND AND AIMS: Phenotypic switch of vascular smooth muscle cells (VSMC) plays a key role in the pathogenesis of atherosclerosis and restenosis after artery intervention. Transcription repressor element 1-silencing transcription factor (REST) has been identified as key regulator of VSMC proliferation. In the present study, we sought to investigate the potential association of E3-ubiquitin ligase β-TRCP...
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