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GMRSP encoded by lncRNA H19 regulates metabolic reprogramming and alleviates aortic dissection

17 Feb 2025

Abstract excerpt

Metabolic disturbances are hallmarks of vascular smooth muscle cell (VSMC) phenotypic transitions, which play a critical role in the pathogenesis of aortic dissection (AD). In this study, we identify and characterize glucose metabolism regulatory protein (GMRSP), a protein encoded by lncRNA H19. Using VSMC-specific GMRSP induction in knock-in mice, adeno-associated virus-mediated GMRSP overexpression, and...

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PMID: 39966416
DOI: 10.1038/s41467-025-57011-5

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