Article
High-resolution KIR and HLA genotyping in three Chinese ethnic minorities reveals distinct origins.
HLA - 1 Apr 2024
Tao Sudan, Norman Paul J, You Xuan, Kichula Katherine M, Dong Lina, Chen Nanying, He Yizhen, Chen Chen, Zhang Wei, Zhu Faming
Abstract excerpt
Polymorphism of killer-cell immunoglobulin-like receptors (KIRs) and their HLA class I ligands impacts the effector activity of cytotoxic NK cell and T cell subsets. Therefore, understanding the extent and implications of KIR and HLA class I genetic polymorphism across various populations is important for immunological and medical research. In this study, we conducted a high-resolution investigation of KIR and...
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