Article
Non-Coding SNPs Regulate Bovine Muscle Satellite Cell Proliferation and Differentiation by Modulating PENK Expression.
International journal of molecular sciences - 20 Aug 2026
Wu Tianyi, Liu Feng, Niu Qunhao, Zhao Zhida, Zhang Lupei, Gao Huijiang, Li Junya, Gao Xue, Xu Lingyang
Abstract excerpt
The functions of noncoding variants associated with complex traits in livestock remain poorly understood. In this study, we investigated two candidate noncoding variants within the XKR4-CHCHD7 locus identified from our previous analysis. Dual-luciferase reporter assays demonstrated allele-specific regulatory activity of these two regions in bovine muscle satellite cells (BMSCs), 293T cells, and C2C12 cells....
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