Spatial, transcriptomic, and epigenomic analyses link dorsal horn neurons to chronic pain genetic predisposition.

doi:10.1016/j.celrep.2024.114876

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Article

Spatial, transcriptomic, and epigenomic analyses link dorsal horn neurons to chronic pain genetic predisposition.

Cell reports - 26 Nov 2024

Arokiaraj Cynthia M, Leone Michael J, Kleyman Michael, Chamessian Alexander, Noh Myung-Chul, Phan BaDoi N, Lopes Bettega C, Corrigan Kelly A, Cherupally Vijay Kiran, Yeramosu Deepika, Franusich Michael E, Podder Riya, Lele Sumitra, Shiers Stephanie, Kang Byungsoo, Kennedy Meaghan M, Chen Viola, Chen Ziheng, Mathys Hansruedi, Dum Richard P, Lewis David A, Qadri Yawar, Price Theodore J, Pfenning Andreas R, Seal Rebecca P

Abstract excerpt

Key mechanisms underlying chronic pain occur within the dorsal horn. Genome-wide association studies (GWASs) have identified genetic variants predisposed to chronic pain. However, most of these variants lie within regulatory non-coding regions that have not been linked to spinal cord biology. Here, we take a multi-species approach to determine whether chronic pain variants impact the regulatory genomics of dorsal...

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Identifiers

PMID: 39453813
DOI: 10.1016/j.celrep.2024.114876
PMCID: PMC11801220

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