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Article

BRD4 contributes to the cytokine-induced acquisition of an IL-13RA2-positive inflammatory fibroblast phenotype.

Journal of Crohn's & colitis - 5 Aug 2026

Frascatani Rachele, Serra Mattia Alberto, Iannucci Andrea, Colella Marco, Maresca Claudia, Marafini Irene, Lolli Elisabetta, Sena Giorgia, Divizia Andrea, Guida Andrea Martina, Sica Giuseppe Sigismondo, Monteleone Giovanni

Abstract excerpt

BACKGROUND AND AIMS: Inflammatory bowel diseases (IBDs) are characterized by chronic intestinal inflammation, in which inflammatory fibroblasts contribute to epithelial damage and amplification of mucosal inflammation. However, the molecular mechanisms regulating their pathogenic activity remain incompletely understood. This study investigated the role of the epigenetic reader BRD4 in the differentiation and...

Topics

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Cell Cycle Proteins
Cells, Cultured
Cytokines
Fibroblasts
Inflammatory Bowel Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nuclear Proteins

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Identifiers

PMID: 42635600
DOI: 10.1093/ecco-jcc/jjag128
PMCID: PMC13501532

Genes

BRD4
CCL2
CSF3
CXCL1
CXCL2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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