Article

IGF2BP3 inhibits IL-13 and IL-4 effects in human airway epithelium and is dysregulated in type 2 disease

2025-07-19

Abstract excerpt

Type 2 immunity encompasses the coordinated cellular responses mainly driven by IL-4 and IL-13 to target extracellular parasites. Uncontrolled, type 2 responses underpin asthma and allergy. At the cellular level, IL-13 and IL-4 bind to receptors IL-13Rα1 and IL-4R and trigger STAT6 phosphorylation leading to the transcription of type 2 mediators. Further regulators of this fundamental pathway remain poorly underst...

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Literature Corpus work: c2b113ec-eaac-55a8-96f7-cf6f9799d0c0
DOI: 10.1101/2025.07.19.665669

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