Causal link between polymyositis and idiopathic pulmonary fibrosis in individuals of European ancestry: A Mendelian randomization and multi-omics study identifying mediators and drug targets.

Abstract excerpt

Polymyositis (PM), an autoimmune muscle disorder, often leads to interstitial lung disease (ILD), including idiopathic pulmonary fibrosis (IPF). However, causality and mechanisms are unclear. This study aimed to investigate the causal effect of PM on IPF risk, identify potential mediating biomarkers through multi-omics analysis, and explore candidate therapeutic drugs. Two-sample Mendelian randomization (MR) was...

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