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Article

Plasma genome-wide mendelian randomization identifies potentially causal genes in idiopathic pulmonary fibrosis.

Respiratory research - 18 Oct 2024

Zhang Kun, Shi Puyu, Li Anqi, Zhou Jiejun, Chen Mingwei

Abstract excerpt

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease with a very poor prognosis. Existing drugs for the treatment of IPF are still insufficient. Therefore, there is still a need to explore new drug targets for preventing and treating IPF. METHODS: We included quantitative trait loci (QTL) for genes, DNA methylation, and proteins in plasma, as well as the summary statistics for IPF. Genetic...

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DNA Methylation
Genetic Predisposition to Disease
Genome-Wide Association Study
Idiopathic Pulmonary Fibrosis
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lung Cancer Treatments and Mutations

Mendelian Randomization Analysis

Quantitative Trait Loci

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Identifiers

PMID: 39425105
DOI: 10.1186/s12931-024-03008-5
PMCID: PMC11490078

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