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Article

Plasma genome-wide mendelian randomization identifies potentially causal genes in idiopathic pulmonary fibrosis.

Respiratory research - 18 Oct 2024

Zhang Kun, Shi Puyu, Li Anqi, Zhou Jiejun, Chen Mingwei

Abstract excerpt

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease with a very poor prognosis. Existing drugs for the treatment of IPF are still insufficient. Therefore, there is still a need to explore new drug targets for preventing and treating IPF. METHODS: We included quantitative trait loci (QTL) for genes, DNA methylation, and proteins in plasma, as well as the summary statistics for IPF. Genetic...

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Identifiers

PMID: 39425105
DOI: 10.1186/s12931-024-03008-5
PMCID: PMC11490078

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