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Article

Hypothyroidism and dermato/polymyositis: a two-sample Mendelian randomization study.

Frontiers in endocrinology - 1 Jan 2024

Li Qianqian, Yang Shaoying, Ma Yan, Huang Huijing, Zhi Langxian, Wang Suli, Lu Liangjing

Abstract excerpt

Objective: Observational studies have revealed a higher probability of hypothyroidism in patients with dermatomyositis (DM) or polymyositis (PM), but there is no consensus on whether hypothyroidism causally influences DM or PM. In the present study, we assessed the causal association between hypothyroidism and the risk of dermatomyositis or polymyositis using two-sample Mendelian randomization (TSMR). Methods:...

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Dermatomyositis
Genetic Predisposition to Disease
Genome-Wide Association Study
Hypothyroidism
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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Identifiers

PMID: 39296720
DOI: 10.3389/fendo.2024.1361581
PMCID: PMC11408279

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